There may be a COVID vaccine through the nose

(Beautiful pictures)

NEW HAVEN, Conn. ( – The appearance of the omicron variation leaves scientists scrambling to determine how much protective current COVID-19 vaccines provided against the new strain. However, exciting new research by a team at Yale University has uncovered an entirely new form of vaccination that could be on the way soon. Research suggests that the nasal vaccination could be a useful way to provide additional protection against the coronavirus.

Experiments showed that intranasal vaccination was successful in providing broad-spectrum protection against respiratory viruses that came from different organisms among a group of mice. Meanwhile, syringe-based vaccination (standard photos) cannot reproduce the same robust protection.

“The best immune defense happens at the gate, protecting against viruses trying to get in,” said senior study author Iwasaki, Waldemar Von Zedtwitz Professor of Immunobiology at Yale. university release.

Special antibodies come from nasal vaccines

The mucous membranes of the human body contain their own individual “immune system”, which fights against airborne or food-borne pathogens. When this small immune system kicks in, the barrier tissues produce B cells, which then lead to the secretion of immunoglobin A (IgA). antibody. While a typical injection induces a body-wide immune response, IgA antibodies act exclusively on the mucosa. surface in the nose, stomach and lungs.

Scientists say that IgA-producing cells help protect against intestinal pathogens, but the study’s authors wondered if activating the IgA response might also be helpful in initiating local immune response against respiratory viruses.

In collaboration with scientists from the Icahn School of Medicine at Mount Sinai in New York, the team tested a protein-based vaccine designed to trigger an IgA immune response in mice. Some of the mice received the vaccine by injection, but the researchers used the nasal version on others. They then exposed all the rodents to various strains of influenza.

Notably, the mice given nasal vaccine showed much stronger protection against respiratory flu than other types that were injected. Also, only the nasal vaccine produces antibodies that are able to protect against several different strains of flu, not just the main strain the vaccine is designed to protect against.

Researchers are currently testing nasal vaccine formulations against COVID-19 strain in animal experiments. Professor Iwasaki notes that while both vaccines increase the amount of antibodies in the blood, only the nasal vaccine can release IgA into the lungs.

So, what is the end game here? If trials show the nasal vaccine is both safe and effective, the study authors envision the nasal vaccine working alongside current vaccines. and booster shots.

The research published in the magazine The Science of Immunology. There may be a COVID vaccine through the nose


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