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J&J COVID-19 booster blend enhances immune response after Pfizer vaccination

Using the Johnson & Johnson vaccine as a booster for people initially immunized with the Pfizer/BioNTech vaccine produces a response, researchers said Sunday. immunity is strong and can do much more to protect against serious illness. Pfizer / BioNTech vaccine doses show that using J&J Janssen vaccine as booster induces slower but more sustained antibody responses against the original virus strain, as well as Delta and Beta variants . Their research shows that a faster and stronger immune response falls off more quickly. “Both vaccines raised antibody titers very well. At week 4, neutralizing antibody levels were comparable,” said Dr. Dan Barouch of Beth Israel Deaconess Medical Center and Harvard Medical School, who led the team, told CNN. continued to increase in those vaccinated with J&J. J&J’s vaccine also increases the number of immune cells called CD8 T cells. This T-cell protection doesn’t stop mild infections, but can stop them from progressing to serious illness. “For variants like omicron that can partially evade antibody responses, CD8 T-cell responses may be particularly relevant for protection,” he said. “We think they are related in general but they could become particularly relevant if a variant emerges that can largely escape the antibodies.” There is a lot of concern or speculation that it could lead to at least some degree, possibly a significant degree, of escape from vaccine-induced antibodies. To get a boost, you need a boost to boost both antibody and T-cell responses.” Barouch said his team submitted the findings to a peer-reviewed journal, and in the meantime it has been published. posted online, without peer review, on the MedRxiv preprint server.

Researchers reported Sunday that administering the Johnson & Johnson vaccine as a booster to people initially immunized with the Pfizer/BioNTech vaccine produces a robust and potentially potent immune response. Much more could be done to protect against severe illness, researchers said Sunday.

Their small study of 65 volunteers who were initially given two doses of Pfizer / BioNTech’s vaccine found that using the J&J Janssen vaccine as a booster induces a slower antibody response. but more durable against the original strain, as well as Delta and Beta. they say.

Their research shows that the Pfizer/BioNTech booster produces a faster and stronger immune response, with a faster drop.

“Both vaccines raised antibody titers very well. At week 4, neutralizing antibody levels were similar,” said Dr. Dan Barouch of Beth Israel Deaconess Medical Center and Harvard Medical School, who led the team, told CNN.

But after four weeks, antibody levels began to decrease in those boosted with the Pfizer vaccine while continuing to rise in those given the J&J vaccine. J&J’s vaccine also increases the number of immune cells called CD8 T cells.

Antibodies are a first line of immune defense that can prevent the virus from infecting cells, while T cells enter later and destroy infected cells. This T-cell protection doesn’t prevent mild infections, but can prevent them from progressing to serious illness.

While the study did not include the omicron variant, Barouch said the findings could be important for figuring out how to combat the latest variant.

“For variants like omicron that can partially evade antibody responses, CD8 T-cell responses may be particularly relevant for protection,” he said. “We think they are related in general but they could become particularly relevant if a variant emerges that can largely escape the antibodies.”

“Now we don’t know that for sure about omicrons, but as I’m sure you know, there’s a lot of concern or speculation that it could lead to at least some degree, possibly a significant level. Well, get rid of the vaccine. make antibodies. To boost, you want a boost to increase both antibody and T-cell responses.”

Barouch said his team submitted the findings to a peer-reviewed journal and in the meantime it was published online, without peer review, on preprint server MedRxiv.

https://www.kcra.com/article/study-mix-and-match-jandj-booster-raised-immune-response-after-pfizer-vaccine/38438532 J&J COVID-19 booster blend enhances immune response after Pfizer vaccination

JOE HERNANDEZ

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