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How does delta variation compare to omicron?

The new omicron variant of the coronavirus, with many mutations and seemingly spreading rapidly after being discovered in South Africa, is worrying scientists and government officials. .Delta has managed to take over the entire US in a matter of weeks in early summer, changing the outlook on a country that is rolling out a vaccine and hopefully at a comparable rate. “At the end of June, the seven-day moving average of reported cases was around 12,000. On July 27, the seven-day moving average of the cases reached more than 60,000. The case rate looks like the rate of cases we’ve seen before the vaccine became widely available,” the US Centers for Disease Control and Prevention said on its website. “The delta variant is very contagious, 2x more than the earlier variants.” Delta now accounts for more than 99% of genome-sequenced coronavirus cases in the US, according to the CDC. It remains to be seen whether the omicron will pass delta, but it will be difficult. “Of course, in the US we still have a severe increase in delta variation. We should think about that,” National Institutes of Health Director Dr. Francis Collins told CNN on Monday. The US now averages 70,094 new COVID-19 cases and 730 deaths per day, according to Johns Hopkins University. And JHU says 75% of US intensive care unit beds are occupied, 15% of which are for COVID-19 patients. The shaped structure covers the surface of the virus and is used to attach to human cells so that the virus can infect them. It races through populations, displacing more worrisome variants whose mutations allow them to avoid the effects of vaccines, such as beta variants. mutations seen in Garry told CNN. “But we’ve seen that leap in evolution before,” he added. But just because there are many mutations does not necessarily mean that they will form a small virus. “But he doesn’t see many important mutations that would make the omicron version more contagious than the delta.” “That’s really a big question,” he said. That is a big question. doesn’t bring with it some change that makes delta very contagious. “Given that the omicron lacks so many of the nonmutated mutations that seem to contribute to the delta’s physical enhancement, I wouldn’t be surprised if its intrinsic transmissibility was similar to gamma,” said Trevor Bedford, a co-author of the study. Genomic science and epidemiology Goblin at the University of Washington and Fred Hutchinson Cancer Center in Seattle, said on Twitter. He referenced a September study from researchers at the Broad Institute, who found at least three mutations in the delta variant that they say appear to make it more contagious. like a kind called kappa. Protects against COVID-19Garry found mutations can help omicrons avoid the body’s immune response – especially from previous infections. “It has immune evasion. delta too, before that alpha and beta. Should we be working on a specific vaccine? vaccination, and if you’ve been vaccinated and six months have been it’s been a while since you had Pfizer or Moderna, get a booster, two months from J&J, get a booster,” Collins said. “That’s why, but now let’s add omicrons to the mix,” he said. “And we believe this new variant, which may be coming to our shores, will also be the kind of vaccine and booster that can help you.” completed the first two doses of Moderna or Pfizer/BioNTech vaccine and two months after the single dose of Johnson & Johnson vaccine. Even if a mutation helps the virus become more viable as an airborne pathogen, better ventilation can help prevent transmission.

The new omicron variant of the coronavirus, with many mutations and seemingly spreading rapidly after being discovered in South Africa, is worrying scientists and government officials.

But doctors want to remind Americans that they are facing a rather formidable variant of the coronavirus, and that’s the delta.

Delta has managed to take over the entire US in a matter of weeks in early summer, shifting the outlook on a country that is rolling out a vaccine and hopefully at a comparable rate.

“At the end of June, the seven-day moving average of reported cases was around 12,000. On July 27, the seven-day average of cases reached more than 60,000. This case rate “similar to the rate of cases we’ve seen before vaccination. has been widely available,” said the US Centers for Disease Control and Prevention. says on its website. “The delta variant is very contagious, more than 2 times more than the previous variants.”

Delta now accounts for more than 99% of genetically sequenced coronavirus cases in the US, according to the CDC.

It remains to be seen whether the omicron will pass delta, but it will be difficult.

“Of course, we still have a serious increase in delta variation in the US. We should be thinking about that,” National Institutes of Health Director Dr. Francis Collins told CNN on Monday.

According to Johns Hopkins University, the US currently has an average of 70,094 new COVID-19 cases and 730 deaths per day. And JHU says 75% of the beds in the US intensive care unit are occupied, 15% of which are COVID-19 patients.

Compare omicron and delta

The majority were made of 50 mutants that marked the omicron variant – 32 of which were located on the mutant protein, which is the club-shaped structure that coats the surface of the virus and is used to attach to human cells. so that the virus can infect them. .

But delta has a bunch of scary mutations of its own, and they turned it into the worst version of the virus ever. It races through populations, displacing more worrisome variants whose mutations allow them to evade the effects of vaccines, such as beta variants.

Robert Garry, a virologist at Tulane University, made a direct comparison of the mutations seen in delta and omicron.

Gary told CNN. “But we’ve seen that leap in evolution before,” he added.

“There are definitely hotspots where this virus likes to mutate,” he said. But just because there are many mutations does not necessarily mean that they will form a small virus.

“What all of those changes overall will do to things that are important to this virus, we don’t really know yet,” said Garry.

But he didn’t see many important mutations that would make the omicron version more contagious than delta.

“I mean, things that can affect transmission, I just don’t see a lot of things that would give it a really strong advantage over delta,” he said.

“That’s really the big question. You know, when it gets into a delta population, does it compete more or not?”

Other genetics experts also note that omicrons do not carry some of the changes that make delta so contagious.

Trevor Bedford, a genomic scientist and epidemiologist at the University of Washington and Fred Hutchinson Cancer Centers in Seattle, said on Twitter. He consulted a study in September from researchers at the Broad Institute, who have found at least three mutations in the delta variant that they say appear to make it more transmissible.

Some mutations that increase transmissibility are also seen in dead variants, such as one known as kappa.

Protection against COVID-19

Garry found that mutations can help omicrons evade the body’s immune response – especially from previous infections.

“It has immune evasion,” he said. Delta too, before that was alpha and beta.

Doctors say the immune response generated by vaccination is broader than that caused by natural infection, so people who get vaccinated can still be protected from serious illness.

“Your best defense against delta is to get vaccinated, and if you’ve been vaccinated and six months have passed since you had Pfizer or Moderna, get a booster, two,” Collins told CNN. months from J&J, get a booster shot,” Collins told CNN.

“That’s why, but now let’s add omicrons to the mix,” he said. “And we believe this new variant, which may be coming to our shores, will also be the kind of vaccine and booster that can help you.”

The CDC reinforced its booster guidance Monday, saying that all adults should get a booster shot six months after finishing the first two doses of Moderna or Pfizer/BioNTech vaccine and two months after getting the vaccine. Johnson & Johnson single dose.

And there are no known mutations that would cause the virus to evade precautions like face masks, hand washing and physical distancing. Even if a mutation helps the virus become more viable as an airborne pathogen, better ventilation can help prevent transmission.

Source link How does delta variation compare to omicron?

JOE HERNANDEZ

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