Pfizer Studying 3-Dose COVID Vaccine in Children Under 5 After Short-Term 2-Dose Regime – NBC 6 South Florida

Pfizer said Friday that it changed plans and tested three doses of the COVID-19 vaccine in infants and preschool children instead of the usual two.

The addition of an extra dose comes after a preliminary analysis found that children aged 2 to 4 years did not have the expected strong immune response to particularly low-dose shots.

Pfizer planned to release data from its study of children under the age of 5 later this year. It is not clear how this change will delay the task of immunizing the youngest children.

Pfizer and partner BioNTech say that if the three-dose study is successful, they plan to apply for emergency authorization in the first half of 2022.

A children’s version of the Pfizer vaccine is already available for children 5 to 11 years old, a version that is one-third the dose given to others 12 years of age and older.

For children under the age of 5, Pfizer is testing an even smaller dose, just 3 micrograms or a tenth of the adult dose.

The researchers analyzed a small group of young adults in the study a month after their second dose to see if they had developed the same levels of antibodies against the virus as teenagers and young adults. Vaccinated regularly or not.

Pfizer vaccine research director Kathrin Jansen said Friday on a call with investors that children under 2 have similar antibody levels, but a lower immune response in 2- to 4-year-olds.

So the study is being expanded to evaluate three of those very low-dose shots in children under 5 years of age. That third dose should come at least two months after the child’s second dose.

The companies said no safety concerns were detected in the study.

Jansen cites other data that shows booster shots given to people 16 years of age and older restore strong protection, a leap in immunity that scientists hope will also help fight the virus. new omicron bodies.

The companies are also preparing to test a booster shot for children ages 5 to 11 who have recently received two doses of the vaccine. And they are testing different dosage options for teen boosters.

If the additional pediatric trial is successful, “we’ll have a consistent three-dose approach for all ages,” Jansen said.


The Associated Press Health and Science Division receives support from the Howard Hughes Health Institute’s Science Education Department. AP is solely responsible for all content.

https://www.nbcmiami.com/news/coronavirus/pfizer-to-study-3-dose-covid-vaccine-in-kids-under-5-after-2-shot-regimen-fell-short/2644097/ Pfizer Studying 3-Dose COVID Vaccine in Children Under 5 After Short-Term 2-Dose Regime – NBC 6 South Florida


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