This is Mourinho’s first meeting with Inter since winning the treble in 2010.
But it was not a night to remember for the Portuguese as Roma closed the game after Hakan Calhanoglu scored directly from a corner.
Edin Dzeko another second into his old club’s net and Denzel Dumfries’ diving header ended the contest before half-time.
Inter came in second as city rivals AC Milan took the top spot by taking the lead over Salernitana in a comfortable 2-0 win at the San Siro.
On a day in which injured Milan lost defender Simon Kjaer for the rest of the season after knee surgery, Franck Kessie and Alexis Saelemaekers were targets in the opening half.
Napoli started the day but lost 3-2 at home to Atalanta.
Piotr Zelinski and Dries Mertens put Napoli ahead after Ruslan Malinovskyi’s opener, but second-half goals from Merih Demiral and Remo Freuler gave Atalanta the win.
Real Madrid extended their La Liga lead to eight points with a 2-0 win over Real Sociedad.
Vinicius Junior gave Real the lead two minutes into the restart and Luka Jovic’s close-range header helped open the scoring.
Sevilla overcame Villarreal with a score of 1-0 when Lucas Ocampos scored the winning goal in the 15th minute.
Xavi suffered his first defeat as Barcelona manager as Real Betis finished third with a 1-0 win at the Nou Camp.
Barcelona remained in seventh place after a 79th-minute Betis goal from Juanmi, who had a cool finish after being missed by former Barca striker Cristian Tello.
Defending champions Atletico Madrid lost humbly to Mallorca 2-1 at home.
Atletico took the lead thanks to Matheus Cunha’s dribbling effort in the 68th minute, but Franco Russo equaled from a free kick and Real Madrid loanee Takefusa Kubo took the lead in injury time to win win.
Robert lewandowski scored twice as Bayern Munich trailed Borussia Dortmund by four points with a 3-2 win coming from behind in a dramatic Der Klassiker match.
Julian Brandt put Dortmund ahead after five minutes, but Lewandowski quickly leveled and Kingsley Coman gave Bayern the lead at half-time.
Erling Haaland equalized with a superb save shortly after the break, but Lewandowski moved his 16th goal of the campaign – and 40th of the year – from the penalty spot in the 13th minute.
Dortmund coach Marco Rose has been sent off for the second time for dissent following the penalty decision.
Patrik Schick scored four goals in the second half as third-placed Bayer Leverkusen crushed bottom side Greuther Furth 7-1 for their biggest ever home win in the Bundesliga.
Amine Adli and Edmond Tapsoba gave Leverkusen a 2-0 lead within 17 minutes before Jeremie Dudziak reduced the deficit.
Ecuadorian teenager Piero Hincapie restored the two-goal advantage to Leverkusen as the first half ended and the second half was a display from Schick as the Czech forward scored four goals between 49 and 76 minutes.
Hoffenheim from behind beat Eintracht Frankfurt 3-2 and took fourth place.
Dennis Geiger, Georginio Rutter and Diadie Samassekou are all targets for Hoffenheim, with Rafael Borre – who opened the scoring after 15 minutes – and Goncalo Paciencia answering for Eintracht.
Mainz overcame Wolfsburg in seventh place with a 3-0 win. Jonathan Burkardt and Anton Stach attacked for the first four minutes and Maxence Lacroix headed into his net late in the game.
Sebastian Polter’s double helped Bochum win 3-2 at Augsburg. Gerrit Holtmann also scored for the visitors before Michael Gregoritsch and Daniel Caligiuri provided Augsburg hope in the second half.
Arminia Bielefeld drew 1-1 at home to Cologne when substitute Bryan Lasme saved Salih Ozcan’s opening goal.
Georginio Wijnaldum’s first goal of the season saved leaders Paris St Germain in a 1-1 draw against Lens.
Seko Fofana put Lens ahead shortly after the game ended but Wijnaldum scored in the second minute of stoppage time to give PSG a 13-point lead.
Second-placed Marseille were 2-1 at home by Brest with Romain Faivre and Franck Honorat scoring to open the scoring for Gerson.
Jonathan David and a late Jimmy Giraudon own goal gave Lille a 2-1 win over Troyes, who took the lead after six minutes thanks to Tristan Dingome.
https://www.independent.co.uk/sport/football/inter-milan-jose-mourinho-edin-dzeko-real-madrid-robert-lewandowski-b1969977.html Heartbroken for Jose Mourinho as former club Inter Milan win over Roma